Registered substances
Registered substances
Registered substances
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
- The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
Further information
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Last updated 29 July 2021. Database contains 23355 unique substances and contains information from 104287 dossiers.
| Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
|---|---|---|---|---|---|---|---|---|
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2E)-3-[(tert-butoxycarbonyl)(propan-2-yl)amino]-2-(4-chlorophenyl)prop-2-enoic acid | 813-178-7 | 1489004-27-4 | - | View substance registered dossier |
| CENTIPHARM | Chemin de la Madeleine 06131 GRASSE FRANCE France | France | Active | (2E)-4,4,4-trifluorobut-2-en-1-ol | 835-846-7 | 83706-94-9 | - | View substance registered dossier |
| LES DERIVES RESINIQUES ET TERPENIQUES | 30 rue Gambetta B.P. 206 40105 Dax Cedex France | France | Active | (2E)-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl) but-2-enal | 801-014-7 | 179107-88-1 | - | View substance registered dossier |
| Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2E)-N,N-diethyl-3,7-dimethyl-octa-2,6-dien-1-amine | 814-576-3 | 40267-53-6 | 2020 | View substance registered dossier |
| Esteve Quimica, S.A. | Torre Esteve Passeig de la Zona Franca, 109, 4ª Planta 08038 Barcelona Barcelona Spain | Spain | Active | (2E)-N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide | 811-237-1 | 698387-09-6 | - | View substance registered dossier |
| CHEMICAL INSPECTION & REGULATION SERVICE LIMITED | Regus Harcourt Centre D02 HW77 Dublin Ireland | Ireland | Active | (2E,2'E)-2,4,8,10-tetraoxaspiro[5.5]undecane-3,9-diylbis(2-methylpropane-2,1-diyl) bis(2-cyano-3-(3,4-dimethoxyphenyl)acrylate) | 830-560-9 | 2233585-18-5 | - | View substance registered dossier |
| Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2E,4E)-2,4-decadienoic acid | 250-149-2 | 30361-33-2 | 2020 | View substance registered dossier |
| Symrise AG | Mühlenfeldstraße 1 37603 Holzminden Germany | Germany | Active | (2E,4E)-2-methyl-5-phenyl-penta-2,4-dienal | 919-772-3 | - | - | View substance registered dossier |
| - | - | - | - | (2E,4E)-Isobutyl-deca-2,4-dienamide | 457-600-4 | 18836-52-7 | - | View substance registered dossier |
| Výzkumný ústav organických syntéz a.s. | č.p. 296 533 54 Rybitví Czech Republic | Czech Republic | Active | (2E,4E,7S)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoic acid, ammonium salt (1:1) | 619-006-5 | 942519-41-7 | - | View substance registered dossier |
| Novartis Integrated Services Limited | Ringaskiddy IE Ringaskiddy Cork Ireland | Ireland | Active | (2E,4R)-5-{[1,1’-biphenyl]-4-yl}-4-[(tert-butoxycarbonyl)amino]-2-methylpent-2-enoic acid | 695-654-2 | 1012341-48-8 | 2014 | View substance registered dossier |
| Merck Schuchardt OHG | Eduard-Buchner-Str. 85662 Hohenbrunn Germany | Germany | Active | (2H)chloroform | 212-742-4 | 865-49-6 | - | View substance registered dossier |
| EURISO-TOP | Parc des Algorithmes Bât. Homère 91194 SAINT-AUBIN France | France | Active | (2H)chloroform | 212-742-4 | 865-49-6 | - | View substance registered dossier |
| Acros Organics bv | Janssen Pharmaceuticalaan 3a B-2440 Geel Belgium | Belgium | Active | (2H)chloroform | 212-742-4 | 865-49-6 | - | View substance registered dossier |
| Sigma-Aldrich Company Limited | The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom | United Kingdom | No longer Valid | (2H)chloroform | 212-742-4 | 865-49-6 | 2021 | View substance registered dossier |
| SIGMA-ALDRICH CHEMIE GMBH | Riedstrasse 2 89555 Steinheim Germany | Germany | Active | (2H)chloroform | 212-742-4 | 865-49-6 | 2020 | View substance registered dossier |
| knoell Germany - OR - E13 | Konrad-Zuse-Ring 25 68163 Mannheim Germany | Germany | Active | (2H)chloroform | 212-742-4 | 865-49-6 | - | View substance registered dossier |
| PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | (2R)-1-(2,4-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one | 823-704-7 | 126918-17-0 | - | View substance registered dossier |
| PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | (2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one | 819-998-1 | 135270-08-5 | - | View substance registered dossier |
| PIERRE FABRE MEDICAMENT | 45 place Abel Gance 92654 Boulogne France | France | Active | (2R)-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl beta-D-glucopyranoside | 805-675-2 | 102340-61-4 | - | View substance registered dossier |
| Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Kalkstrasse 218 51377 Leverkusen Germany | Germany | Cease Manufacture | (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol | 841-499-2 | 1340593-59-0 | 2020 | View substance registered dossier |
| MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid | 951-764-5 | - | - | View substance registered dossier |
| BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid | 444-040-0 | 52950-18-2 | 2010 | View substance registered dossier |
| Patheon Austria GmbH & Co KG | St. Peterstrasse 25 A-4020 Linz Austria | Austria | Active | (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid | 444-040-0 | 52950-18-2 | 2013 | View substance registered dossier |
| sanofi chimie | 82 avenue Raspail 94250 Gentilly France | France | Active | (2R)-2-(2-chlorophenyl)-2-hydroxyethanoic acid | 444-040-0 | 52950-18-2 | 2010 | View substance registered dossier |
| Clarochem Ireland Ltd | damastown mulhuddart dn 15 dublin Ireland | Ireland | Active | (2R)-2-(3-Benzoylphenyl)propanoic acid, 1-Deoxy-1-(octylamino)-D-glucitol salt | 944-007-5 | - | - | View substance registered dossier |
| Syngenta Ltd | Jealott’s Hill International Research Centre RG42 6EY Bracknell Berkshire United Kingdom | United Kingdom | No longer Valid | (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid; Fluazifop-P | 617-435-2 | 83066-88-0 | 2021 | View substance registered dossier |
| Deretil S.A. | Villaricos, s/n 04618 Cuevas del Almanzora Almeria Spain | Spain | Active | (2R)-2-amino-2-phenylacetamide | 420-370-0 | 6485-67-2 | 2011; 2012; 2014 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (2R)-2-amino-2-phenylacetamide | 420-370-0 | 6485-67-2 | - | View substance registered dossier |
| Arran Chemical Company Ltd | Monksland Industrial Estate N37DN24 Athlone Co. Roscommon Ireland | Ireland | Active | (2R)-2-aminobutan-1-ol L-tartrate monohydrate | 814-787-0 | 153078-05-8 | - | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20090 RODANO Milano Italy | Italy | No longer Valid | (2R)-3-(acetyloxy)-2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]propyl (2S)-2-amino-3-methylbutanoate hydrochloride | 691-736-7 | 960495-42-5 | - | View substance registered dossier |
| OLON Spa | Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | Italy | Active | (2R)-3-(acetyloxy)-2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]propyl (2S)-2-amino-3-methylbutanoate hydrochloride | 691-736-7 | 960495-42-5 | 2012; 2014; 2016 | View substance registered dossier |
| Barentz Service S.p.A. | via Privata Goito, 8 20037 Paderno Dugnano Italy | Italy | Active | (2R)-3-cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | 700-669-5 | 2788-28-5 | - | View substance registered dossier |
| Biosint S.p.A. | Via Murillo 16 04013 Sermoneta Italy | Italy | Active | (2R)-3-cyano-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride | 700-669-5 | 2788-28-5 | 2019 | View substance registered dossier |
| BASF SE | Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | Germany | Active | (2R)-4-hydroxybutan-2-aminium (2S)-hydroxy(phenyl)acetate | 810-156-9 | 1236049-43-6 | 2016 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2R)-6-fluoro-2-(oxiran-2-yl)chromane | 930-890-4 | - | 2019 | View substance registered dossier |
| CU Chemie Uetikon GmbH | Raiffeisenstrasse 4 77933 Lahr Baden-Württemberg Germany | Germany | Active | (2R)-acetoxy(phenyl)acetic acid | 610-598-0 | 51019-43-3 | - | View substance registered dossier |
| Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2R)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide - (2R,3R)-2,3-dihydroxysuccinic acid - propan-2-ol (2:1:1) | 947-841-8 | - | - | View substance registered dossier |
| Pfizer Ltd | Ramsgate Road (IPC 979) CT13 9NJ Sandwich Kent United Kingdom | United Kingdom | No longer Valid | (2R*,3S*)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1R)-10-camphorsulfonate | 427-100-0 | - | 2021 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2R*,3S*)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethylnaphthalene; reaction mass of: (1R*,2S*)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethylnaphthalene | 425-570-1 | 185429-83-8 | - | View substance registered dossier |
| Givaudan France SAS - OR1 | 55, Rue de la voie des Bans CS500024 95102 Argenteuil Cedex France | France | Active | (2R*,3S*)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethylnaphthalene; reaction mass of: (1R*,2S*)-2-acetyl-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethylnaphthalene | 425-570-1 | 185429-83-8 | - | View substance registered dossier |
| Evonik Operations GmbH | Rellinghauser Straße 1-11 45128 Essen Germany | Germany | Active | (2R,2'R)-3,3'-disulfanediylbis(2-((S)-2-aminopropanamido)propanoic acid) | 850-779-3 | 115888-13-6 | - | View substance registered dossier |
| sanofi chimie | 82 avenue Raspail 94250 Gentilly France | France | Active | (2R,3R)-2,3-bis(acetyloxy)butanedioic acid - 3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine (1:1) | 920-610-9 | - | - | View substance registered dossier |
| MINAKEM Beuvry Production SAS | 145, Chemin des Lilas 59310 Beuvry-la-Forêt France | France | Active | (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid | 672-585-6 | 50583-51-2 | - | View substance registered dossier |
| Excella GmbH & Co. KG | Nuernberger Str. 12 90537 Feucht Germany | Germany | Active | (2R,3R)-2,3-Dihydroxybutanedioic acid--(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide (1/1) | 947-840-2 | - | - | View substance registered dossier |
| PROCOS SpA | via Matteotti 249 28062 Cameri Piemonte Italy | Italy | Active | (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate | 815-196-0 | 1175536-50-1 | - | View substance registered dossier |
| L.C.M. TRADING SPA | via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy | Italy | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | - | View substance registered dossier |
| ACS DOBFAR S.p.A | Viale Addetta 4/12 20067 Tribiano Milano Italy | Italy | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate | 408-050-9 | 76855-69-1 | - | View substance registered dossier |
| [Confidential] | - | - | - | (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-yl-thiobutyramide | 609-299-8 | 368421-58-3 | - | View substance registered dossier |
| Krka, d. d., Novo mesto | Smarjeska cesta 6 SI-8501 Novo mesto Slovenia | Slovenia | Active | (2R,3R)-3-(3-(Benzyloxy)phenyl-2-methylpentanoic acid | 805-624-4 | 1367878-84-9 | - | View substance registered dossier |
| DSM Nutritional Products GmbH | Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany | Germany | Cease Manufacture | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | 479-560-7 | 989-51-5 | 2019 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | 479-560-7 | 989-51-5 | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol [(1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid | 948-743-8 | - | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride | 948-534-1 | 1639208-51-7 | - | View substance registered dossier |
| PCAS | 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France | France | Active | (2R,3R,4R)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)-5-methoxytetrahydrofuran | 857-987-3 | 64363-77-5 | - | View substance registered dossier |
| Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane-2-carbonitrile | 856-564-0 | 1355357-49-1 | - | View substance registered dossier |
| [Confidential] | - | - | - | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | 807-677-9 | 817204-32-3 | - | View substance registered dossier |
| F.I.S. Fabbrica Italiana Sintetici S.p.a. | Viale Milano, 26 36075 Montecchio Maggiore (VI) Veneto Italy | Italy | Active | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate | 807-677-9 | 817204-32-3 | - | View substance registered dossier |
| Bayer AG | Kaiser-Wilhelm-Allee 51373 Leverkusen Germany | Germany | Active | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 606-239-2 | 19130-96-2 | 2011; 2012 | View substance registered dossier |
| Gilead Sciences Ireland UC | IDA Business &Technology Park Carrigtohill Cork Cork Ireland | Ireland | Active | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile | 857-885-9 | 1191237-69-0 | - | View substance registered dossier |
| N.V. Ajinomoto OmniChem S.A. | Cooppallaan 91 9230 Wetteren Oost-Vlaanderen Belgium | Belgium | Cease Manufacture | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate | 612-107-5 | 61259-48-1 | 2019 | View substance registered dossier |
| Janssen Pharmaceutica N.V. | Turnhoutseweg 30 2340 Beerse Belgium | Belgium | Active | (2R,3R,4S,5R)-2-(acetoxymethyl)-6-oxotetrahydro-2H-pyran-3,4,5-triyl triacetate | 612-107-5 | 61259-48-1 | - | View substance registered dossier |
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